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Friday 18 October 2019
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Topic: *** Editor's Pick

October 17, 2019
The latest study, published in PLOS ONE, is the first to investigate the use of the technique in a large local cohort of people previously diagnosed with knee OA. The results show that the technique can distinguish between healthy and OA knees, and that it works well both in general practice and hospital settings
A new way of diagnosing and assessing knee osteoarthritis (OA) has moved a step closer with a major study paving the way for its use in research and clinical practice.
 
The technique involves attaching small microphones to knees, and detecting high frequency sounds from the joint components as people perform sitting standing movements.
 
October 17, 2019
The Digital Health Assistant (DHA) will use machine learning to develop an understanding of the person being supported and continues to adapt to their needs over time based on interactions; this allows DHA to provide emailed content and support specific to the individual’s needs, making it more effective than current alternatives
A digital social enterprise and four UK health charities are coming together to harness the power of artificial intelligence (AI) to create the UK’s first AI coaching tool of its kind to support long-term health conditions.
 
Reason Digital is teaming up with Parkinson’s UK, the Stroke Association, Muscular Dystrophy UK and the MS Society to develop the project, which is set to transform the way medical advice and information is delivered to almost half-a-million people in the UK.
 
October 16, 2019
Overall, results from ETNA-AF at one year showed low rates of bleeding (major and gastrointestinal), intracranial haemorrhage and ischaemic events during the first year of edoxaban therapy
One-year results from the ongoing Global ETNA-AF (Edoxaban Treatment in routiNe clinical prActice) registry, providing a snapshot of characteristics and outcomes from a broad range of NVAF patients receiving edoxaban in routine clinical care, were presented at the Great Wall International Congress of Cardiology (GW-ICC) 2019, in Beijing, China.
 
October 16, 2019
Initial studies established that collagen was key to keeping breast and pancreatic cancers stiff and inaccessible to treatments. In contrast, tumours arising from the nervous system were relatively soft and lacking in collagen
Using a non-invasive imaging technique that measures the stiffness of tissues gives crucial new information about cancer architecture and could aid the delivery of treatment to the most challenging tumours, new research shows.
 
Magnetic resonance elastography was able to visualise and measure how stiff and dense tumours are in mice. The technique, which can be implemented on conventional clinical MRI scanners, may help select the best treatment course for some cancer patients.
 
October 16, 2019
The collaborative study was funded by the National Institute for Health Research (NIHR), and a team from the Universities of Sheffield, Warwick, Birmingham and Queen Mary University in London, together with the Mental Health Foundation have published a new policy briefing into its findings
Researchers from the University of Sheffield School of Health and Related Research (ScHARR) in the UK have made a series of recommendations for NHS mental health trusts to change the way they collect and use patient feedback to improve the quality of care for inpatients.
 
As part of the study, staff and patients were interviewed across NHS mental health Trusts in England, and it was found that few are collecting patient feedback to actively improve services.
 
October 15, 2019
This discovery allows new therapeutic options to be considered in the prevention and treatment of allergic asthma
In a study published in Nature Immunology, Professors Thomas Marichal (FRS-FNRS Research Associate, Welbio and ERC investigator) and Fabrice Bureau (Welbio investigator) and their teams from GIGA ULiège identified that particular neutrophils are recruited into the lung and are responsible for allergic sensitisation and asthma development. 
 
October 15, 2019
Aneurysms are often called a silent killer, because patients can display no symptoms until the aneurysm bursts. Around 80% of all patients with a ruptured aneurysm die from the condition
A team from the University of Dundee School of Medicine has devised a test that detects the presence of desmosine, an amino acid that diseased aortas release into the blood and urine, which they believe can improve the diagnosis and monitoring of aortic aneurysms while possibly aiding effort to develop new therapies to slow down their progression.
 
October 15, 2019
The results of two extension studies confirm the long-term safety of tildrakizumab and show high and durable PASI and PGA response rates
Almirall has announced the presentation of the results of 14 abstracts about efficacy and safety of long-term tildrakizumab treatment at the 28th EADV Congress by Almirall and SUN Pharma to bring the newest data about psoriasis biological therapies. 
 
October 10, 2019
On 2 October, 2019, United European Gastroenterology, the European Association for Gastroenterology, Endoscopy and Nutrition, and the Healthy Stomach Initiative, recognised World Stomach Day
Originally initiated by the Health Stomach Initiative, World Stomach Day aims to raise awareness of the global burden of gastric diseases and the need for further research in the field as well as improved prevention and treatment strategies. 
 
October 10, 2019
Initial tests of the new National Record Locator service gave ambulance staff in pilot areas of the UK the ability to see whether someone they were treating had a mental health crisis plan, joining up services and helping patients get the best possible care
Ambulance staff in areas of the UK will soon be able to access the mental health crisis plans of emergency patients while on the move, following the successful first pilot phase of the National Record Locator.
 
Initial tests of the new National Record Locator service gave ambulance staff in pilot areas the ability to see whether someone they were treating had a mental health crisis plan, joining up services and helping patients get the best possible care.
 
October 7, 2019
The largest study ever to look at why an expensive and commonly–used group of drugs fails some patients with Crohn’s disease has identified a genetic marker which could individualise drug treatment
A UK-wide collaboration led by the University of Exeter, Royal Devon & Exeter NHS Foundation Trust and the Wellcome Sanger Institute, has demonstrated that a genetic variant carried by 40% of the population explains why some patients develop antibodies against the anti-TNF drugs, infliximab and adalimumab and lose response.
 
October 7, 2019
The paper highlights the importance of an individual exercise plan for each patient, taking into account personal history, cancer treatment, response to exercise, and personal preferences
Patients with cancer should receive a tailored exercise prescription to protect their heart, reports a paper published in the European Journal of Preventive Cardiology.
 
'Cancer patients are often less active than adults without cancer,' said author Dr Flavio D'Ascenzi, University of Siena, Italy. 'However, exercise is essential for patients diagnosed with cancer who are under treatment, irrespective of the type of treatment.'
 
October 3, 2019
The idea of the ‘one-two punch’ arose out of earlier research in which researchers at the Netherlands Cancer Institute exploited a weak point in resistant skin cancer cells in order to destroy them

A classic boxing move, the ‘one-two punch’, could also be effective against cancer: a left jab knocks cancer cells senseless, quickly followed by a right hook that knocks them out altogether.

Researchers at the Netherlands Cancer Institute have shown that cancer cells are vulnerable to this kind of approach.

October 3, 2019
A new partnership between scientists at the University of Birmingham and Novo Nordisk aims to discover new treatments for people suffering from fatty liver disease

The University of Birmingham’s Centre for Liver and Gastrointestinal Research and Novo Nordisk have joined forces in a collaboration supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre.

The NIHR Birmingham BRC brings together the expertise of University Hospitals Birmingham NHS Foundation Trust (UHB) and the University of Birmingham, both members of Birmingham Health Partners (BHP).

October 1, 2019
The method revealed previously undiscovered genes linked to the disease, and accurately predicted whether thousands of other people had the disease

Scientists have developed a computer method that may help improve understanding and treatment of Crohn's disease.

The study, published in Genome Medicine, used artificial intelligence to examine genetic signatures of Crohn's in 111 people. The method revealed previously undiscovered genes linked to the disease, and accurately predicted whether thousands of other people had the disease.

October 1, 2019
Despite the low incidence, most patients die from the disease and therefore new effective therapies are urgently needed

New data have shown for the first time that targeted therapy can improve the outcome of patients diagnosed with advanced cholangiocarcinoma.

October 1, 2019
NHS Vale of York CCG rolls out evidence-based intervention technology to help reduce unplanned hospital care as nationally emergency care admissions reach 10-year high

An innovative AI-based nursing service has been introduced across Vale of York to identify patients at risk of unplanned care attendances and admissions, helping to improve quality of life and reduce emergency admissions.

The pioneering project, commissioned by NHS Vale of York CCG, tackles the NHS’ ever-increasing demand for urgent and emergency care services, as highlighted in figures released by NHS Digital recently which showed that emergency admissions have peaked nationally, increasing 28% over the last ten years.

October 1, 2019
This international collaboration of researchers used WGS to analyse tumours from patients who had been diagnosed as having triple negative breast cancers

Whole genome sequencing (WGS) of tumour cells could help predict the prognosis of a patient's cancer and offer clues to identify the most effective treatment, suggests an international study published in Nature Medicine.

September 30, 2019
Once-daily QMF149 demonstrated superior improvement in lung function versus mometasone furoate, meeting primary endpoint

Novartis has announced that investigational, once-daily, fixed-dose inhaled QMF149 (indacaterol acetate and mometasone furoate or IND/MF) was superior to mometasone furoate (MF) in improving trough forced expiratory volume in one second (FEV1) after 26 weeks, meeting the primary endpoint of the Phase III PALLADIUM clinical trial.

September 27, 2019
The calculator uses a model that takes into account available data about the patient, as well as blood test results. It can be used to identify if a person is likely to have type 1 diabetes, to reduce misdiagnosis
A new calculator developed by the University of Exeter in the UK will help clinicians classify whether a patient has type 1 or type 2 diabetes, ensuring they get the best treatment and reducing complications.
 
The calculator uses a model that takes into account available data about the patient, as well as blood test results. It can be used to identify if a person is likely to have type 1 diabetes, to reduce misdiagnosis. 
 
September 26, 2019
Researchers identified or confirmed 14 regions in the human genome associated with the size and function of the left ventricle - each containing genes that regulate the early development of heart chambers and the contraction of heart muscle
Genetic research led by Queen Mary University of London could open the way to earlier identification of people at risk of heart failure and to the development of new treatments.
 
September 26, 2019
A study compiled the best available evidence to examine the odds of high blood pressure in patients with moderate and severe gum disease. A total of 81 studies from 26 countries were included in the meta-analysis
People with periodontitis have a greater likelihood of hypertension, according to a study published in Cardiovascular Research.
 
September 26, 2019
To understand this higher risk of severe flares and ultimately help women with lupus experience healthy pregnancies and successful outcomes, a team of US researchers explored the possible role of gut microbiota in the link between pregnancy and the exacerbation of lupus
A highly gender-biased disease, lupus afflicts females some nine times more than males. 
 
Because of the disease's unpredictable turns and debilitating flares - the risks of which are elevated in postpartum women - females with the disease are often advised to avoid pregnancy altogether.
 
September 25, 2019
The survey, conducted in August 2019, asked 401 bone specialists from 11 European countries about their experience of osteoporosis and fragility fracture management
A new European survey, released by UCB, reveals that bone specialists believe osteoporosis and fragility fractures are neglected and under prioritised by their healthcare systems, and action needs to be taken.
 
The survey, conducted in August 2019, asked 401 bone specialists from 11 European countries about their experience of osteoporosis and fragility fracture management.