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Thursday 22 August 2019
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Topic: Cardiovascular

June 16, 2019
Study also reveals venous thromboembolism and epilepsy as potential novel comorbidities
A study has shown increased rates of type I diabetes and inflammatory bowel disease (IBD) in patients that go on to develop rheumatoid arthritis (RA).1 
 
Results of the study demonstrate that the RA group reported significantly more cases of inflammatory bowel disease (1.9% vs. 0.5%, p<0.001) and type I diabetes (1.3% vs. 0.4%, p=0.01) versus controls.1
 
June 13, 2019
ApoB:A1 ratio and metabolomic lipoprotein signatures identified as new biomarkers for cardiovascular risk in juvenile SLE patients
The results of a study presented at EULAR 2019 identify ApoB:A1 ratio and metabolomic lipoprotein signatures as potential  biomarkers for cardiovascular risk in patients with  juvenile-onset systemic lupus erythematosus (JSLE).1
 
In depth metabolomics was used to investigate dyslipidaemia and cardiovascular risk in a cohort of patients with  JSLE. Unbiased hierarchical clustering stratified patients by metabolomic profile and revealed three distinct groups.
 
June 10, 2019
Oral semaglutide is an investigational once-daily oral glucagon-like peptide-1 receptor agonist
Findings presented from two Phase IIIa clinical trials evaluated oral semaglutide 14mg vs Jardiance® (empagliflozin 25mg) in PIONEER 2 and oral semaglutide 14mg versus Victoza® (liraglutide 1.8mg) in PIONEER 4 over 52 weeks in adults with type 2 diabetes. 
 
Data from both trials were presented at the American Diabetes Association (ADA) 79th Scientific Sessions. 
 
May 29, 2019
The PHARM-CHF trial investigated whether regularly seeing a pharmacist improves adherence to heart failure medications

Elderly patients with heart failure who see a pharmacist once a week are more likely to take their tablets and be active in daily life, according to late breaking results from the PHARM-CHF randomised controlled trial presented at Heart Failure 2019.1

May 22, 2019
Coronary angiography is an invasive procedure that provides an X-ray outline of the arteries supplying blood to the heart but there has been controversy over when to use it

Imaging provides a more precise diagnosis of a heart attack that can be used to individualise treatment. That is the main message of an expert consensus paper published in the European Heart Journal,1 and presented at EuroPCR 2019 in Paris.2

Heart attacks are diagnosed and treated using coronary angiography, an invasive procedure which provides an X-ray outline of the arteries supplying blood to the heart. Invasive imaging of the arteries gives more detail but there has been controversy over when to use it.

May 22, 2019
The worse outcome in women is largely attributable to the fact that women had about half the chance of having a shockable initial rhythm compared to men

Women who have a cardiac arrest outside the hospital setting are less likely to receive resuscitation from bystanders and more likely to die than men, according to new research published in the European Heart Journal.1

March 18, 2019
The REPAIR study showed that treatment with macitentan was associated with significant improvement in RV function in patients with PAH
 
Actelion has announced an interim analysis from the Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension (REPAIR) study of Opsumit® (macitentan) that shows treatment with macitentan in patients with pulmonary arterial hypertension (PAH) was associated with significant improvements in right ventricular (RV) function, including reversal of RV remodelling and reduced pulmonary vascular resistance (PVR). 
 
March 15, 2019
Rod Tucker on what pharmacists should tell patients interested in high intensity exercises

The NHS has described exercise as a miracle cure that is able to reduce the risk of major illnesses such as heart disease, stroke, Type 2 diabetes and even cancer.
 

March 4, 2019
Substantial data have been published since the last Scientific Statement in 2005 showing the importance of measuring blood pressure outside of the clinic setting
The accurate measurement of blood pressure is essential for the diagnosis and management of hypertension, a major risk factor for heart disease and stroke, according to an updated American Heart Association scientific statement on blood pressure measurement in humans, published in the American Heart Association journal Hypertension.
 
March 4, 2019
Randomised clinical trial demonstrates safety and efficiency of a common and simplified protocol for pacemaker and defibrillator surveillance based on remote monitoring only
Two-year data from the RM-ALONE Trial1 evaluating the safety and workflow efficiency of remote cardiac monitoring with remote interrogations were recently published in the European Heart Journal.
 
The authors analysed the efficacy of Biotronik Home Monitoring® as a follow-up method after the implantation of cardiac implantable electronic devices (CIEDs) without regular in-person evaluations with a physician. 
 
December 11, 2018
The study was a retrospective analysis of all patients with acute ST-segment elevation myocardial infarction treated at Triemli Hospital in Switzerland between 2000 and 2016

Women are being urged to call an ambulance immediately if they have heart attack symptoms, following research showing they wait longer than men to get help. The study has been published in European Heart Journal: Acute Cardiovascular Care, a publication of the European Society of Cardiology (ESC).1

November 29, 2018
Researchers investigated cardiac function in relation to diagnosed OSA and self-reported snoring from data available through UK Biobank

Obstructive sleep apnoea (OSA) and snoring may lead to earlier impairment of cardiac function in women than in men, according to a new study presented at the annual meeting of the Radiological Society of North America.

Moreover, the findings suggested that OSA may be vastly underdiagnosed among snorers.

November 9, 2018

NHS England spends over £1bn per year on diabetes prescriptions, data has revealed.
 
A report published yesterday (8 November) by NHS Digital showed that the cost of prescriptions for diabetes has grown by £422m in a decade, reaching more than £1bn in 2017/18.
 

October 30, 2018
Interviews were conducted to characterise two healthcare practitioners’ adoption of peripherally inserted central catheters into their clinical practices and the resulting clinical and economic benefits associated with their use

Disclaimer

This case study reflects the individual experiences of two healthcare practitioners and does not represent a scientific study or present clinical evidence. Results for other clinicians or institutions will vary. Please consult manufacturer’s instructions for use for relevant warnings, indications, and counterindications.
 

Disclosure

October 24, 2018

An implanted cardiac defibrillator (ICD) can effectively put a stop to any underlying cardiac arrhythmia, a study has found [24 October 2018].
 
In a long-term observational study involving 1,500 patients, researchers from MedUni Vienna's Department of Medicine II (division of cardiology) have shown that the programming selected for the implanted defibrillators (ICDs) plays a major role.
 
It was found that the most "defensive" possible procedure was safe and, at the same time, significantly reduced inappropriate therapy.

October 24, 2018

Global biotechnology company Amgen’s Repatha® (evolocumab) has been selected as a Rapid Uptake Product by the Accelerated Access Collaborative (AAC), the Department of Health and Social Care (DHSC) has announced [October 23 2018].
 

October 11, 2018

A one-off DNA test could spot people at risk of a heart attack in adulthood much earlier in life for just £40, according to new research.
 
The study, part-funded by the charity the British Heart Foundation and published in the Journal of the American College of Cardiology, developed a new scoring system to identify those at risk because of their genetics.
 
It costs £40, making it a “cost effective” way of helping preventing heart disease according to the report’s authors.
 

October 11, 2018

A one-off DNA test could spot people at risk of a heart attack in adulthood much earlier in life for just £40, according to new research.
 
The study, part-funded by the charity the British Heart Foundation and published in the Journal of the American College of Cardiology, developed a new scoring system to identify those at risk because of their genetics.
 
It costs £40, making it a “cost effective” way of helping preventing heart disease according to the report’s authors.
 

October 8, 2018
Mechanical thrombectomy using state of the art devices has revolutionised the treatment of patients with severe disabling strokes due to large vessel occlusion with proven efficacy in re-establishing intracranial circulation and improving patient outcomes
Stroke is the second single most common cause of death in the world, with 6.7 million stroke-related deaths each year.1 The burden of disease (disability, illness and premature deaths) caused by stroke is set to double worldwide by 2030.1 Stroke affects 152,000 people annually in the UK; that is 1 person every 3 minutes 27 seconds.2 Large vessel occlusion often causes severe strokes and is associated with high mortality, morbidity, poor clinical outcomes and high societal costs.3
 
September 11, 2018
With new candidates identified from different pathophysiological pathways, new technologies for measurement and more perspectives of data integration, the transformation is ongoing in the field of cardiac biomarkers
September 11, 2018
The development of PCSK9 inhibitors is a great example of serendipity, clever exploitation of a fascinating genetic observation, and rational drug development using monoclonal antibody technology in the 21st century
September 11, 2018
Patients with chronic kidney disease have an elevated risk for bleeding with declining glomerular filtration rate, even in the absence of anticoagulants, but also have an elevated risk of thromboembolism
Chronic kidney disease (CKD), a reduction in renal function with decreasing glomerular filtration rate (GFR) is increasing in incidence as well as in prevalence due to a growing elderly population. The progressive reduction in GFR to less than 60ml/min (modest renal insufficiency; mRI) or severe renal insufficiency (sRI; with GFR <30ml/min) may lead to end stage renal disease (ESRD) with a requirement for chronic haemodialysis (CHD).
 
September 11, 2018
From the breakthroughs of early pioneers to the present day, the quest to improve outcomes and reduce complications goes on
June 20, 2018
Idorsia launches PRECISION – Phase 3 study with aprocitentan for resistant hypertension management in adults

Swiss biopharmaceuticals business Idorsia has announced that the first patient has been enrolled into PRECISION, a Phase 3 study to investigate the efficacy and safety of aprocitentan for managing resistant hypertension in adults [June 20 2018].