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Friday 18 October 2019
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Topic: Cardiovascular

October 15, 2019
Aneurysms are often called a silent killer, because patients can display no symptoms until the aneurysm bursts. Around 80% of all patients with a ruptured aneurysm die from the condition
A team from the University of Dundee School of Medicine has devised a test that detects the presence of desmosine, an amino acid that diseased aortas release into the blood and urine, which they believe can improve the diagnosis and monitoring of aortic aneurysms while possibly aiding effort to develop new therapies to slow down their progression.
 
October 7, 2019
The paper highlights the importance of an individual exercise plan for each patient, taking into account personal history, cancer treatment, response to exercise, and personal preferences
Patients with cancer should receive a tailored exercise prescription to protect their heart, reports a paper published in the European Journal of Preventive Cardiology.
 
'Cancer patients are often less active than adults without cancer,' said author Dr Flavio D'Ascenzi, University of Siena, Italy. 'However, exercise is essential for patients diagnosed with cancer who are under treatment, irrespective of the type of treatment.'
 
October 3, 2019
A new partnership between scientists at the University of Birmingham and Novo Nordisk aims to discover new treatments for people suffering from fatty liver disease

The University of Birmingham’s Centre for Liver and Gastrointestinal Research and Novo Nordisk have joined forces in a collaboration supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre.

The NIHR Birmingham BRC brings together the expertise of University Hospitals Birmingham NHS Foundation Trust (UHB) and the University of Birmingham, both members of Birmingham Health Partners (BHP).

September 27, 2019
The calculator uses a model that takes into account available data about the patient, as well as blood test results. It can be used to identify if a person is likely to have type 1 diabetes, to reduce misdiagnosis
A new calculator developed by the University of Exeter in the UK will help clinicians classify whether a patient has type 1 or type 2 diabetes, ensuring they get the best treatment and reducing complications.
 
The calculator uses a model that takes into account available data about the patient, as well as blood test results. It can be used to identify if a person is likely to have type 1 diabetes, to reduce misdiagnosis. 
 
September 26, 2019
Researchers identified or confirmed 14 regions in the human genome associated with the size and function of the left ventricle - each containing genes that regulate the early development of heart chambers and the contraction of heart muscle
Genetic research led by Queen Mary University of London could open the way to earlier identification of people at risk of heart failure and to the development of new treatments.
 
September 26, 2019
A study compiled the best available evidence to examine the odds of high blood pressure in patients with moderate and severe gum disease. A total of 81 studies from 26 countries were included in the meta-analysis
People with periodontitis have a greater likelihood of hypertension, according to a study published in Cardiovascular Research.
 
September 20, 2019
The FAD is part of the final guidance to the NHS in England and Wales expected to be published in October 2019
Takeda has announced that the National Institute for Health and Care Excellence (NICE) has issued its Final Appraisal Determination (FAD) recommending Takhzyro®▼ (lanadelumab) subcutaneous injection as an option for preventing recurrent attacks of hereditary angioedema (HAE) in patients aged 12 years and older.
 
The recommendation is only if:
  • patients are eligible for preventive C1-esterase inhibitor (C1-INH) treatment in line with NHS England’s commissioning policy
September 20, 2019
Results from the CONCLUDE trial were presented at the 55th Annual Meeting of the European Association for the Study of Diabetes in Barcelona, Spain
According to new data from the CONCLUDE head-to-head trial, Tresiba® (insulin degludec) showed an overall lower risk of hypoglycaemia at a significantly lower HbA1c, compared with insulin glargine U300 in adults with type 2 diabetes uncontrolled on basal insulin with or without oral anti-diabetic drugs. 
 
September 12, 2019
The analysis included 474 patients presenting to the emergency department with acute coronary syndrome (myocardial infarction and unstable angina)
According to a study published in the European Journal of Cardiovascular Nursing, heart attack symptoms can be gradual or abrupt and both situations are a medical emergency. 
 
The study found that patients with gradual symptom onset took eight hours to get medical help compared to 2.6 hours for those with abrupt symptoms. A maximum delay of two hours is recommended to get fast treatment and the best outcomes; serious complications and death are more likely beyond this window.
 
September 10, 2019
This review aims to look at the theory behind targeted temperature management and how it is applied clinically, with attention to new research in this field and its impact on patient survival and neurological recovery
September 6, 2019
This article summarises the key messages from the Fourth Universal Definition of Myocardial Infarction
In August 2018, the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force published an updated universal definition of myocardial infarction (MI).1 This consensus document provides newly revised criteria for the definition of MI,1 driven by recent advances of modern cardiology. So, what was new in this Fourth Universal Definition of MI and how will this consensus paper affect everyday clinical practice?

The condition

September 6, 2019
In an ageing and comorbid population with a high incidence of severely calcified coronary and peripheral lesions, advanced debulking techniques are frequently necessary in order to offer optimal interventional and endovascular treatment results
September 6, 2019
With candidates identified from different pathophysiological pathways, new technologies for measurement and more perspectives of data integration, transformation is occurring in the field of cardiac biomarkers
September 3, 2019
The document highlights how catheter ablation is revolutionising care for this group of common arrhythmias

The European Society of Cardiology (ESC) Guidelines on supraventricular tachycardia have been published in the European Heart Journal, and on the ESC website.

September 3, 2019
The guidelines were developed in collaboration with the European Association for the Study of Diabetes

New European Society of Cardiology (ESC) Guidelines on diabetes, pre-diabetes and cardiovascular diseases have been published.

August 22, 2019
Research funded by the British Heart Foundation puts into question a long-held medical myth that women tend to suffer unusual or 'atypical' heart attack symptoms, and emphasises the need for both sexes to recognise and act on the warning signs
Women who have heart attacks experience the same key symptoms as men, quashing one of the reasons given for women receiving unequal care. 
 
Research funded by the British Heart Foundation puts into question a long-held medical myth that women tend to suffer unusual or 'atypical' heart attack symptoms, and emphasises the need for both sexes to recognise and act on the warning signs.
 
July 4, 2019
Research has shown that calcium-channel blockers may be linked with an increased risk of the bowel condition, diverticulosis
Diverticulosis causes small bulges or pouches to appear in the lining of the intestine. Particularly affecting the elderly (as many as 65% of over 85s may be affected), diverticulosis can in some cases lead to a medical emergency if the pouches become infected or burst.
 
The new early-stage research finding comes from a team of scientists led by Imperial College London, who investigated the effectiveness and side effects of three common blood pressure medications: ACE-inhibitors, beta-blockers and calcium channel blockers.
June 16, 2019
Study also reveals venous thromboembolism and epilepsy as potential novel comorbidities
A study has shown increased rates of type I diabetes and inflammatory bowel disease (IBD) in patients that go on to develop rheumatoid arthritis (RA).1 
 
Results of the study demonstrate that the RA group reported significantly more cases of inflammatory bowel disease (1.9% vs. 0.5%, p<0.001) and type I diabetes (1.3% vs. 0.4%, p=0.01) versus controls.1
 
June 13, 2019
ApoB:A1 ratio and metabolomic lipoprotein signatures identified as new biomarkers for cardiovascular risk in juvenile SLE patients
The results of a study presented at EULAR 2019 identify ApoB:A1 ratio and metabolomic lipoprotein signatures as potential  biomarkers for cardiovascular risk in patients with  juvenile-onset systemic lupus erythematosus (JSLE).1
 
In depth metabolomics was used to investigate dyslipidaemia and cardiovascular risk in a cohort of patients with  JSLE. Unbiased hierarchical clustering stratified patients by metabolomic profile and revealed three distinct groups.
 
June 10, 2019
Oral semaglutide is an investigational once-daily oral glucagon-like peptide-1 receptor agonist
Findings presented from two Phase IIIa clinical trials evaluated oral semaglutide 14mg vs Jardiance® (empagliflozin 25mg) in PIONEER 2 and oral semaglutide 14mg versus Victoza® (liraglutide 1.8mg) in PIONEER 4 over 52 weeks in adults with type 2 diabetes. 
 
Data from both trials were presented at the American Diabetes Association (ADA) 79th Scientific Sessions. 
 
May 29, 2019
The PHARM-CHF trial investigated whether regularly seeing a pharmacist improves adherence to heart failure medications

Elderly patients with heart failure who see a pharmacist once a week are more likely to take their tablets and be active in daily life, according to late breaking results from the PHARM-CHF randomised controlled trial presented at Heart Failure 2019.1

May 22, 2019
Coronary angiography is an invasive procedure that provides an X-ray outline of the arteries supplying blood to the heart but there has been controversy over when to use it

Imaging provides a more precise diagnosis of a heart attack that can be used to individualise treatment. That is the main message of an expert consensus paper published in the European Heart Journal,1 and presented at EuroPCR 2019 in Paris.2

Heart attacks are diagnosed and treated using coronary angiography, an invasive procedure which provides an X-ray outline of the arteries supplying blood to the heart. Invasive imaging of the arteries gives more detail but there has been controversy over when to use it.

May 22, 2019
The worse outcome in women is largely attributable to the fact that women had about half the chance of having a shockable initial rhythm compared to men

Women who have a cardiac arrest outside the hospital setting are less likely to receive resuscitation from bystanders and more likely to die than men, according to new research published in the European Heart Journal.1

March 18, 2019
The REPAIR study showed that treatment with macitentan was associated with significant improvement in RV function in patients with PAH
 
Actelion has announced an interim analysis from the Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension (REPAIR) study of Opsumit® (macitentan) that shows treatment with macitentan in patients with pulmonary arterial hypertension (PAH) was associated with significant improvements in right ventricular (RV) function, including reversal of RV remodelling and reduced pulmonary vascular resistance (PVR).