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Sunday 21 July 2019
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Topic: Latest News

July 18, 2019
Ribociclib in combination with fulvestrant will be available on the NHS with immediate effect, providing approximately 5300 a year in England and Wales with a new option for their advanced breast cancer
Novartis has announced that Kisqali® (ribociclib) has been recommended by the National Institute for Health and Care Excellence (NICE) for use on the NHS in combination with fulvestrant, where exemestane plus everolimus is the most appropriate alternative,for the treatment of women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) locally advanced or metastatic breast cancer who have received prior endocrine therapy.
July 18, 2019
Research has shown that projection neurons are damaged by the body's own immune cells, and that this damage could underpin the brain shrinkage and cognitive changes associated with multiple sclerosis
Scientists have discovered that a specific brain cell known as a 'projection neuron' has a central role to play in the brain changes seen in multiple sclerosis (MS). 
The research, published in Nature, shows that projection neurons are damaged by the body's own immune cells, and that this damage could underpin the brain shrinkage and cognitive changes associated with MS. These new findings provide a platform for specific new MS therapies that target damaged brain cells to be developed.
July 11, 2019
Authorisation based on GEMINI pivotal trials in which Dovato achieved non-inferior efficacy compared to a dolutegravir-based, three-drug regimen through 48 weeks, with no cases of resistance
ViiV Healthcare has announced that the European Commission has granted marketing authorisation for Dovato (dolutegravir/lamivudine) for the treatment of HIV-1 infection in adults and adolescents above 12 years of age weighing at least 40kg, with no known or suspected resistance to the integrase inhibitor class, or lamivudine.
July 11, 2019
The results of joint studies by Sobi™ and Sanofi were presented at ISTH 2019, the 27th Congress of the International Society on Thrombosis and Haemostasis, in Melbourne, Australia, on 7, 8 and 9 July 2019.
Clinical study data on switching haemophilia A and B patients from on-demand treatment to extended half-life (EHL) prophylaxis showed a positive impact on clinical outcomes, with improvements in quality of life (QoL) and reduced annual bleeding rates (ABR). 
The results of these joint studies by Sobi™ and Sanofi were presented at ISTH 2019, the 27th Congress of the International Society on Thrombosis and Haemostasis, in Melbourne, Australia, on 7, 8 and 9 July 2019.
July 11, 2019
In the first study of its kind, researchers from the University of Surrey investigated nurses’ awareness of cancer warning signs, cancer screening and the frequency of discussions held with patients about early cancer diagnosis in eight countries across the world
Nurses’ knowledge of cancer and screening processes varies significantly across the globe – potentially resulting in unnecessary deaths where knowledge falls short - new research in the European Journal of Oncology Nursing reports.
In the first study of its kind researchers from the University of Surrey investigated nurses’ awareness of cancer warning signs, cancer screening and the frequency of discussions held with patients about early cancer diagnosis in eight countries across the world.
July 2, 2019
A Norwegian study has an increased risk of developing haematological cancers in non-MS siblings of MS patients, compared with both MS patients and the general population
New results of a 65-year follow-up study of nearly 7000 Norwegian patients with multiple sclerosis (MS) suggest that patients may have a greater overall risk of developing cancer than the general population, with an especially high risk of cancer in respiratory organs, urinary organs and the central nervous system.
Cancer risk among MS patients compared with the non-MS population:
  • Respiratory cancer: 66% increase in risk
  • Central nervous system (CNS): 52% increase in risk
July 1, 2019
The test looks at 19 different variants of the DPYD gene that indicate susceptibility with the toxicity of these drugs; DPYD activity is important as it normally acts to breakdown 5-FU.
The Cancer and Haematology Centre at the Churchill Hospital in Oxford and the Horton General Hospital in Banbury have introduced a genetic test that helps predict dangerous side-effects of chemotherapy.
June 20, 2019
The purpose of the study was to assess the drug’s pharmacokinetics, efficacy and safety for treatment of MAS and to confirm the proposed dose regimen
SOBI has announced that new research demonstrating the effects of emapalumab in patients with macrophage activation syndrome (MAS), a form of secondary haemophagocytic lymphohistiocytosis (HLH) complicating systemic juvenile idiopathic arthritis (sJIA), was presented at the EULAR/Paediatric Rheumatology European Society (PReS) Scientific Congress in Madrid.  
June 20, 2019
Crohn’s & Colitis UK and IBD UK campaign to promote better care for everyone with IBD and provide greater access to psychological and dietetic support and more timely diagnosis
IBD UK, a partnership of 17 professional and patient organisations chaired by Crohn’s & Colitis UK, believe that people with IBD should receive safe, consistent, high-quality and personalised care, wherever they live and whatever their age, from diagnosis to treatment and ongoing monitoring, but unfortunately this is not currently the case.
June 18, 2019
This approval is based on data from the Phase III SOLO-1 trial, which showed that Lynparza, after a median follow-up of 40.7 months, lowered the risk of disease progression or death by 70% than with placebo
AstraZeneca and MSD have announced that the European Commission (EC) has approved Lynparza (olaparib) as a 1st-line maintenance treatment for women with BRCA-mutated advanced ovarian cancer.
The licensed indication is as a maintenance treatment of adult patients with advanced (FIGO stages III and IV) BRCA1/2-mutated (germline and/or somatic) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of 1st-line platinum-based chemotherapy.
June 16, 2019
Study also reveals venous thromboembolism and epilepsy as potential novel comorbidities
A study has shown increased rates of type I diabetes and inflammatory bowel disease (IBD) in patients that go on to develop rheumatoid arthritis (RA).1 
Results of the study demonstrate that the RA group reported significantly more cases of inflammatory bowel disease (1.9% vs. 0.5%, p<0.001) and type I diabetes (1.3% vs. 0.4%, p=0.01) versus controls.1
June 15, 2019
Initial pilot data support the use of new neurostimulation treatment in a larger study in patients who have failed current standard of care
The results of a study suggest that electro stimulation of the vagus nerve could provide a novel treatment approach for patients with rheumatoid arthritis.1 
This is a really exciting development. For many patients suffering from rheumatoid arthritis, current treatments don’t work, or aren’t tolerated,” said Professor Thomas Dörner, Chairperson of the Scientific Programme Committee, EULAR. 
June 14, 2019
In the European Union alone, an extra one million employees could be in work each day if early interventions were more widely accessible for people with rheumatic and musculoskeletal diseases (RMDs)
EULAR has launched the Time2Work campaign to raise awareness of the impact rheumatic and musculoskeletal diseases (RMDs) have, not only on individuals, but wider society, productivity and our economies and what can be done to improve this situation.
Affecting one quarter of the EU population (120 million), RMDs are the biggest cause of sick leave and premature retirement due to physical disability. As one of the main causes of physical disability, RMDs contribute considerably to loss of productivity in the workplace.
June 14, 2019
Over half of patients and rheumatologists report diagnosis within six weeks as the most problematic standard of care
The results of a large pan-European survey presented at EULAR 2019 investigated significant gaps in rheumatoid arthritis care across 16 patient-centred Standards of Care (SoC) in rheumatoid arthritis.1  
June 14, 2019
Huge impact of pain and sleep on mental health raises questions about the level of care offered to patients
A survey has highlighted the significant impact of rheumatic and musculoskeletal diseases (RMDs) on mental health and a worrying lack of psychological care.1
June 13, 2019
A collaboration between hospitals and pharmacies in Cheshire and Merseyside has saved the NHS £11 million – and improved patient care
Pharmacies in Cheshire and Merseyside in the UK are being notified by their local hospital when a patient is discharged who might need help understanding changes to their medicines following their stay.
June 13, 2019
ApoB:A1 ratio and metabolomic lipoprotein signatures identified as new biomarkers for cardiovascular risk in juvenile SLE patients
The results of a study presented at EULAR 2019 identify ApoB:A1 ratio and metabolomic lipoprotein signatures as potential  biomarkers for cardiovascular risk in patients with  juvenile-onset systemic lupus erythematosus (JSLE).1
In depth metabolomics was used to investigate dyslipidaemia and cardiovascular risk in a cohort of patients with  JSLE. Unbiased hierarchical clustering stratified patients by metabolomic profile and revealed three distinct groups.
June 13, 2019
Study includes data from over 8000 people with psoriatic arthritis from four Nordic countries
The results of a study presented EULAR 2019 suggest that overall cancer risk is not linked to tumour necrosis factor inhibitor (TNFi) use in psoriatic arthritis.
June 13, 2019
Pixantrone has been available to patients since 2012 following a conditional approval in Europe
Servier has announced that the European Commission (EC) has approved the conversion of the conditional approval of Pixuvri® (pixantrone) into a standard marketing authorisation as a single agent for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma.
June 13, 2019
Study reports no vaccine infections in children given live-attenuated booster vaccine while on immune suppressing therapies
A study presented at EULAR 2019, jointly organised with the Paediatric Rheumatology Society (PReS), demonstrate no vaccine infections, and no disease flare, in the 234 rheumatic patients who received live-attenuated booster vaccination while taking immune suppressing therapies.1
June 12, 2019
Cardiovascular health and physical activity levels of prostate cancer patients improve following successful interventions by community pharmacies, new research in the British Medical Journal reports
In the first study of its kind, researchers from the University of Surrey, funded by the Movember Foundation in partnership with Prostate Cancer UK, developed and tested the feasibility of community pharmacies delivering programmes to improve levels of physical activity and diet of men with prostate cancer and those who have successfully completed treatment for the disease. 
June 12, 2019
Decision based on data from Phase III head-to-head study stopped early due to an overall survival efficacy benefit versus sunitinib, a current standard of care

Bristol-Myers Squibb has announced that the Scottish Medicines Consortium (SMC) has decided to fund the combination of Opdivo® (nivolumab) plus Yervoy® (ipilimumab) for use within NHS Scotland as a first-line treatment option for an advanced form of the most common type of kidney cancer, renal cell carcinoma (RCC), specifically in previously-untreated patients who are considered of intermediate- and poor-prognostic risk.

June 10, 2019
Oral semaglutide is an investigational once-daily oral glucagon-like peptide-1 receptor agonist
Findings presented from two Phase IIIa clinical trials evaluated oral semaglutide 14mg vs Jardiance® (empagliflozin 25mg) in PIONEER 2 and oral semaglutide 14mg versus Victoza® (liraglutide 1.8mg) in PIONEER 4 over 52 weeks in adults with type 2 diabetes. 
Data from both trials were presented at the American Diabetes Association (ADA) 79th Scientific Sessions. 
June 10, 2019
An upsurge in demand for proton beam therapy was predicted as the centenary of the discovery of the proton was celebrated at a major scientific conference
Proton beam therapy, an innovative form of radiotherapy that delivers cancer treatment in a more targeted manner, has recently arrived in the UK through the Rutherford Cancer Centres and an NHS facility. 
As the number of patients treated with this precision therapy grows, there is a debate about the benefits that this innovative treatment can bring.