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Sunday 19 May 2019
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Topic: Paediatrics

April 25, 2019
A report describes how a new battery of tests enables researchers to distinguish patients with IBS from healthy children and identifies correlations between certain microbes and metabolites with abdominal pain
To improve the treatment of children with IBS, investigators have developed a sophisticated way to analyse the microbial and metabolic contents of the gut. 
 
April 24, 2019
Research illuminates the relationship between eczema and food allergy

Scratching the skin triggers a series of immune responses culminating in an increased number of activated mast cells in the small intestine, according to research conducted in mice.

This newly identified skin-gut communication helps illuminate the relationship between food allergy and atopic dermatitis. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and led by researchers at Boston Children's Hospital.1

April 15, 2019
Identification of the allergic triggers of rhinitis is crucial in order to implement adequate avoidance measures in both atopic and non-atopic patients; moreover, this identification can help administer specific therapies, such as allergen immunotherapy
Rhinitis is an inflammatory disorder of the nasal mucosa clinically defined by two or more symptoms of nasal itching, sneezing, anterior or posterior rhinorrhoea, and nasal blockage.1
 
April 12, 2019
An eight-year hunt for the cells that drive the extreme childhood food allergy eosinophilic oesophagitis has identified a potential new way to treat the disease while also raising questions about a dietary supplement taken to reduce bowel inflammation
An eight-year hunt for the cells that drive the extreme childhood food allergy eosinophilic esophagitis (EoE) has identified a potential new way to treat the disease while also raising questions about a dietary supplement often taken to reduce bowel inflammation.
 
The study, led by experts at Cincinnati Children's Hospital Medical Center, is posted online in the Journal of Clinical Investigation1 and will be published in print in May. 
 
April 12, 2019
Researchers have effectively prevented the binding of peanut allergens with IgE to suppress the allergic reaction to peanuts using a first-in-class design of allergen-specific inhibitors
In a study published in the Proceedings of the National Academy of Sciences, researchers at the University of Notre Dame in the US have effectively prevented the binding of peanut allergens with IgE to suppress the allergic reaction to peanuts using a first-in-class design of allergen-specific inhibitors.
 
April 4, 2019
Different models should be evaluated to overcome specific transition items such as barriers to successful outcomes, and poor compliance and complications, in order to improve quality of life for the future adult
Transition is defined as the purposeful, planned movement of adolescents and young adults from a child-centred to adult-oriented health care system.1
 
March 21, 2019
Scientists at the University of Surrey and University College London have revealed an innovative in vitro method that can help to develop easy to swallow medicine for children and older people
In an article published by the European Journal of Pharmaceutical Sciences, scientists compared traditional sensory tests and a new in vitro method that was able to explain why smaller multiparticulates eased the travel of medicine from the mouth into the throat and body, reducing mouth residue.
 
The test let scientists easily screen different compositions of the carrier liquid and concentration of the particulates, in order to make swallowing as easy as possible.
 
March 18, 2019
The role of the allergy specialist is critical in risk identification, diagnosis and management of potentially severe allergic reactions in both children and adults
Allergies are a major ongoing problem, especially in Western countries. Currently, it is estimated that about a quarter of the world's population suffers from some type of allergy, mainly due to allergic rhinitis or allergic bronchial asthma.
 
However, the most dangerous reactions (anaphylaxis) usually occur through allergic reactions to foods, drugs and Hymenoptera (for example, wasps, bees, ants, etc) bites.
 
The Big Eight
March 4, 2019
CHMP recommends Dupixent® (dupilumab) for use in adults and adolescents 12 years and older as add on maintenance treatment for certain forms of severe asthma
The European Medicines Agency’s
Committee for
February 28, 2019
After completing up to four years of egg oral immunotherapy treatment, certain study participants were able to safely incorporate egg into their diet for five years
New research regarding egg oral immunotherapy (eOIT) has been presented at the annual American Academy of Allergy, Asthma and Immunology conference in San Francisco.
 
February 11, 2019
A study in identical twin toddlers has helped scientists to identify the first gene mutation that can single-handedly cause juvenile idiopathic arthritis
Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease.
 
By investigating the DNA of individual blood cells of both children and then modelling the genetic defect in a mouse model, the research team led by Adrian Liston (VIB-KU Leuven) was able to unravel the disease mechanism. The findings may help to develop an appropriate treatment as well.
 
January 15, 2019
The findings of a study published in Nature Medicine might inform research to develop microbiome-based therapies to prevent or treat food allergy
Scientists at the University of Chicago have found that gut microbes from healthy human infant donors transplanted into mice protected animals exposed to milk from experiencing allergic reactions, while gut microbes transplanted from infants allergic to milk did not.
 
The study, published in Nature Medicine,1 was supported in part by NIH’s National Institute of Allergy and Infectious Diseases. 
 
December 17, 2018
There are scant data that describe how often pregnant women deliberately stop eating a specific food item in order to prevent future food allergies in their newborns
Pregnant women routinely swear off alcohol and tobacco to boost their chances of having a healthy baby. What about common food allergens like nuts and milk?
 
December 17, 2018
The researchers hope the Pediatric Asthma Risk Score will become the most common tool used by medical practitioners to predict asthma and help prevent the common airway disease from developing
Scientists at Cincinnati Children's Hospital Medical Center in the US have created and tested a decision tool that appears to be the most accurate, non-invasive method yet developed to predict asthma in young children.
 
The researchers hope the Pediatric Asthma Risk Score (PARS) will become the most common tool used by medical practitioners to predict asthma and help prevent the common airway disease from developing.
 
December 7, 2018
Researchers at the Karolinska Institutet in Sweden have published results showing that online cognitive behavioural therapy can be useful in treating gastrointestinal disorders in children when no physical cause can be found

Cognitive behavioural therapy (CBT) online can be useful in treating gastrointestinal disorders in children when no physical cause can be found.

This is the viewpoint of researchers at Karolinska Institutet in Sweden that is described in a new study published in the journal Clinical Gastroenterology and Hepatology.1

December 3, 2018
The study explored how different exposures during pregnancy, birth or childhood modulate asthma-related immune responses in children
The prevalence of allergic diseases has increased significantly over the last decades, creating substantial financial and societal burdens. Due to this, researchers are trying to discover new approaches to the prevention and treatment of these diseases. 
 
A new PhD thesis from the University of Eastern Finland shows that there is a link between immune responses and diverse early life exposures, such as obstetric factors, farm dust and air pollution. Some changes in immune responses are visible up until adolescence.
November 29, 2018
CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks.

Children with cancer at Great Ormond Street Hospital in London are this week starting a new therapy treatment tailored to target patients’ specific cancer cells.
 
The CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks. 
 
Royal Manchester Children’s Hospital is also offering the immunotherapy treatment, and Newcastle upon Tyne Hospitals NHS Foundation Trust will join next month.
 

November 29, 2018
CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks.

Children with cancer at Great Ormond Street Hospital in London are this week starting a new therapy treatment tailored to target patients’ specific cancer cells.
 
The CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks. 
 
Royal Manchester Children’s Hospital is also offering the immunotherapy treatment, and Newcastle upon Tyne Hospitals NHS Foundation Trust will join next month.
 

November 20, 2018
PALISADE (Peanut Allergy oral Immunotherapy Study of AR101 for Desensitization) was an international, randomised (3:1), double-blind, placebo-controlled, Phase III trial to evaluate the efficacy and safety of AR101 in patients with peanut allergy

Aimmune Therapeutics has announced that the New England Journal of Medicinehas published the full results of the landmark Phase III PALISADE clinical trial of AR101, Aimmune’s investigational biologic oral immunotherapy for desensitisation of patients with peanut allergy. PALISADE is the largest and first successful Phase III peanut allergy immunotherapy trial to date.

October 25, 2018

The European Commission has granted Kigabeq paediatric use marketing authorisation (PUMA) following the recommendation of the Committee for Medicinal Products for Human Use (CHMP).
 
Kigabeq is meant for the treatment of infantile spasms, or West’s syndrome, which is an uncommon and severe form of epilepsy associated with a highly-resistant seizure type and a rapid psychomotor regression. It can also be used to treat partial epilepsy in infants and children from one month to seven years of age.
 

October 25, 2018

The European Commission has granted Kigabeq paediatric use marketing authorisation (PUMA) following the recommendation of the Committee for Medicinal Products for Human Use (CHMP).
 
Kigabeq is meant for the treatment of infantile spasms, or West’s syndrome, which is an uncommon and severe form of epilepsy associated with a highly-resistant seizure type and a rapid psychomotor regression. It can also be used to treat partial epilepsy in infants and children from one month to seven years of age.
 

October 17, 2018

The Child health in 2030 in England: comparisons with other wealthy countries report, published [15 October] by the Royal College of Paediatrics and Child Health (RCPCH), compared England with European and other western countries known as the EU15+.
 
Researchers used long-term historical data to project outcomes for children and young people’s health in 2030.
 

October 17, 2018
Pharmacists must implement new validation processes from today (17 October) to prioritise the limited stocks of EpiPen junior 150 microgram (mcg), the Department of Health and Social Care (DHSC) and NHS England have said.

Pharmacists must implement new validation processes from today (17 October) to prioritise the limited stocks of EpiPen junior 150 microgram (mcg), the Department of Health and Social Care (DHSC) and NHS England have said.

Following ‘critical’ shortages of the device, the DHSC and NHS England asked pharmacists to validate both private and NHS prescriptions before ordering and supplying the device to a patient.

June 28, 2018
First cannabinoid prescription medicine to be approved in the US endorses Epidiolex to treat two rare forms of childhood-onset epilepsy

The first cannabinoid prescription in the US has been given the green light by the US Food and Drug Administration (FDA) [June 25 2018].
 
GW Pharmaceuticals’ Epidiolex has been approved to treat two rare forms of childhood onset epilepsy - Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome.