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Sunday 24 March 2019
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Topic: Paediatrics

March 19, 2019
Diagnostic procedures in allergy have been greatly modified (and improved) by molecular allergy tools that not only identify the molecular allergen that causes sensitisation but also provide personalised therapeutic solutions

Allergies are the most common immune system disorders. Their prevalence is continuously increasing, especially in Western countries, where they affect more than 25% of the population.1

March 18, 2019
The role of the allergy specialist is critical in risk identification, diagnosis and management of potentially severe allergic reactions in both children and adults
Allergies are a major ongoing problem, especially in Western countries. Currently, it is estimated that about a quarter of the world's population suffers from some type of allergy, mainly due to allergic rhinitis or allergic bronchial asthma.
 
However, the most dangerous reactions (anaphylaxis) usually occur through allergic reactions to foods, drugs and Hymenoptera (for example, wasps, bees, ants, etc) bites.
 
The Big Eight
March 4, 2019
CHMP recommends Dupixent® (dupilumab) for use in adults and adolescents 12 years and older as add on maintenance treatment for certain forms of severe asthma
The European Medicines Agency’s
Committee for
February 28, 2019
After completing up to four years of egg oral immunotherapy treatment, certain study participants were able to safely incorporate egg into their diet for five years
New research regarding egg oral immunotherapy (eOIT) has been presented at the annual American Academy of Allergy, Asthma and Immunology conference in San Francisco.
 
February 11, 2019
A study in identical twin toddlers has helped scientists to identify the first gene mutation that can single-handedly cause juvenile idiopathic arthritis
Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease.
 
By investigating the DNA of individual blood cells of both children and then modelling the genetic defect in a mouse model, the research team led by Adrian Liston (VIB-KU Leuven) was able to unravel the disease mechanism. The findings may help to develop an appropriate treatment as well.
 
January 15, 2019
The findings of a study published in Nature Medicine might inform research to develop microbiome-based therapies to prevent or treat food allergy
Scientists at the University of Chicago have found that gut microbes from healthy human infant donors transplanted into mice protected animals exposed to milk from experiencing allergic reactions, while gut microbes transplanted from infants allergic to milk did not.
 
The study, published in Nature Medicine,1 was supported in part by NIH’s National Institute of Allergy and Infectious Diseases. 
 
December 17, 2018
There are scant data that describe how often pregnant women deliberately stop eating a specific food item in order to prevent future food allergies in their newborns
Pregnant women routinely swear off alcohol and tobacco to boost their chances of having a healthy baby. What about common food allergens like nuts and milk?
 
December 17, 2018
The researchers hope the Pediatric Asthma Risk Score will become the most common tool used by medical practitioners to predict asthma and help prevent the common airway disease from developing
Scientists at Cincinnati Children's Hospital Medical Center in the US have created and tested a decision tool that appears to be the most accurate, non-invasive method yet developed to predict asthma in young children.
 
The researchers hope the Pediatric Asthma Risk Score (PARS) will become the most common tool used by medical practitioners to predict asthma and help prevent the common airway disease from developing.
 
December 7, 2018
Researchers at the Karolinska Institutet in Sweden have published results showing that online cognitive behavioural therapy can be useful in treating gastrointestinal disorders in children when no physical cause can be found

Cognitive behavioural therapy (CBT) online can be useful in treating gastrointestinal disorders in children when no physical cause can be found.

This is the viewpoint of researchers at Karolinska Institutet in Sweden that is described in a new study published in the journal Clinical Gastroenterology and Hepatology.1

December 3, 2018
The study explored how different exposures during pregnancy, birth or childhood modulate asthma-related immune responses in children
The prevalence of allergic diseases has increased significantly over the last decades, creating substantial financial and societal burdens. Due to this, researchers are trying to discover new approaches to the prevention and treatment of these diseases. 
 
A new PhD thesis from the University of Eastern Finland shows that there is a link between immune responses and diverse early life exposures, such as obstetric factors, farm dust and air pollution. Some changes in immune responses are visible up until adolescence.
November 29, 2018
CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks.

Children with cancer at Great Ormond Street Hospital in London are this week starting a new therapy treatment tailored to target patients’ specific cancer cells.
 
The CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks. 
 
Royal Manchester Children’s Hospital is also offering the immunotherapy treatment, and Newcastle upon Tyne Hospitals NHS Foundation Trust will join next month.
 

November 29, 2018
CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks.

Children with cancer at Great Ormond Street Hospital in London are this week starting a new therapy treatment tailored to target patients’ specific cancer cells.
 
The CAR-T treatment involves collecting and using a patient’s own immune cells to fight the cancer over a number of weeks. 
 
Royal Manchester Children’s Hospital is also offering the immunotherapy treatment, and Newcastle upon Tyne Hospitals NHS Foundation Trust will join next month.
 

November 20, 2018
PALISADE (Peanut Allergy oral Immunotherapy Study of AR101 for Desensitization) was an international, randomised (3:1), double-blind, placebo-controlled, Phase III trial to evaluate the efficacy and safety of AR101 in patients with peanut allergy

Aimmune Therapeutics has announced that the New England Journal of Medicinehas published the full results of the landmark Phase III PALISADE clinical trial of AR101, Aimmune’s investigational biologic oral immunotherapy for desensitisation of patients with peanut allergy. PALISADE is the largest and first successful Phase III peanut allergy immunotherapy trial to date.

October 25, 2018

The European Commission has granted Kigabeq paediatric use marketing authorisation (PUMA) following the recommendation of the Committee for Medicinal Products for Human Use (CHMP).
 
Kigabeq is meant for the treatment of infantile spasms, or West’s syndrome, which is an uncommon and severe form of epilepsy associated with a highly-resistant seizure type and a rapid psychomotor regression. It can also be used to treat partial epilepsy in infants and children from one month to seven years of age.
 

October 25, 2018

The European Commission has granted Kigabeq paediatric use marketing authorisation (PUMA) following the recommendation of the Committee for Medicinal Products for Human Use (CHMP).
 
Kigabeq is meant for the treatment of infantile spasms, or West’s syndrome, which is an uncommon and severe form of epilepsy associated with a highly-resistant seizure type and a rapid psychomotor regression. It can also be used to treat partial epilepsy in infants and children from one month to seven years of age.
 

October 17, 2018

The Child health in 2030 in England: comparisons with other wealthy countries report, published [15 October] by the Royal College of Paediatrics and Child Health (RCPCH), compared England with European and other western countries known as the EU15+.
 
Researchers used long-term historical data to project outcomes for children and young people’s health in 2030.
 

October 17, 2018
Pharmacists must implement new validation processes from today (17 October) to prioritise the limited stocks of EpiPen junior 150 microgram (mcg), the Department of Health and Social Care (DHSC) and NHS England have said.

Pharmacists must implement new validation processes from today (17 October) to prioritise the limited stocks of EpiPen junior 150 microgram (mcg), the Department of Health and Social Care (DHSC) and NHS England have said.

Following ‘critical’ shortages of the device, the DHSC and NHS England asked pharmacists to validate both private and NHS prescriptions before ordering and supplying the device to a patient.

June 28, 2018
First cannabinoid prescription medicine to be approved in the US endorses Epidiolex to treat two rare forms of childhood-onset epilepsy

The first cannabinoid prescription in the US has been given the green light by the US Food and Drug Administration (FDA) [June 25 2018].
 
GW Pharmaceuticals’ Epidiolex has been approved to treat two rare forms of childhood onset epilepsy - Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome.
 

June 1, 2018
Health and Social Care Committee identifies key areas associated with childhood obesity, which demand urgent attention from government

The Health and Social Care Committee has called on the UK government to make it clear that childhood obesity is “everyone’s business”.

March 13, 2018
In year one of the partnership there will 40 students overall (split over two eight week placement blocks), this will increase to 60 in year two and three (split over three placement blocks.)

Students at the University of Surrey in the UK are being given the chance to work at one of the world’s leading children’s hospitals as a result of a new partnership with Great Ormond Street Hospital (GOSH).

September 26, 2017
In particular, the guideline establishes the role of new molecular-based component-specific IgE testing as part of a comprehensive approach to diagnosis

 

A new guideline published by the Standards of Care Committee of the British Society for Allergy & Clinical Immunology (BSACI) aims to bring together the latest science in order to improve the diagnosis and management of peanut and tree nut allergy.1

November 13, 2015
Patient Status Engine and Lifetouch™ "smart bandage" technology now being used as part of a ground-breaking project which aims to transform the way young patients are cared for

A ground-breaking project at Birmingham Children’s Hospital is using wireless technology developed by Isansys Lifecare to predict deterioration in seriously ill children and potentially save thousands of young lives.

November 13, 2015
Patient Status Engine and Lifetouch™ "smart bandage" technology now being used as part of a ground-breaking project which aims to transform the way young patients are cared for

A ground-breaking project at Birmingham Children’s Hospital is using wireless technology developed by Isansys Lifecare to predict deterioration in seriously ill children and potentially save thousands of young lives.

October 16, 2015
Bedwetting is a common medical condition that can and should be treated (1)