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Tuesday 19 February 2019
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Topic: Pathology and diagnostics

January 18, 2019
Rapid blood tests used by the NHS are unable to rule out tuberculosis and should be replaced with a new, more accurate test, a study has found
Researchers from Imperial College London have shown that rapid blood tests used by the NHS are unable to rule out tuberculosis (TB) and should be replaced with a new, more accurate test.
Diagnosing and treating the condition early is essential for the health of the patient as well as for preventing the spread of TB to others. There is therefore a need for rapid, convenient tests to rule out a TB diagnosis in suspected cases based on a blood sample.
January 15, 2019
Academics and health professionals are combining their expertise to trial new technology which could speed up the diagnosis and treatment for thousands of hepatitis and HIV patients
Late diagnosis of blood-borne viruses (BBV), such as HIV and hepatitis, remains high in the UK despite efforts to increase testing among those at risk of infection.
Experts at Teesside University and South Tees Hospitals NHS Foundation Trust have developed a new software application to assist GPs and health-care workers to make decisions about BBV- testing in real time.
December 13, 2018
There is growing evidence that the composition of the microbiome is a promising predictive tool for disease and for patient response to therapy in conditions such as IBD, cancer and liver disease
BiomX Ltd, a microbiome company developing customised phage therapies,  has entered into a collaboration with Janssen Research & Development to utilise BiomX’s XMarker microbiome-based biomarker discovery platform. The XMarker platform will be used to stratify responders and non-responders to inflammatory bowel disease (IBD) therapeutics.
The collaboration was facilitated by Johnson & Johnson Innovation Limited.
December 7, 2018
Novartis's BYL719 is in late-stage development, and Qiagen expects to provide its companion diagnostic to clinical laboratory partners who will then be ready to offer immediate access to the test upon potential regulatory approvals

Qiagen has announced that a clinical development programme is underway with Novartis to bring to market a molecular test as a companion diagnostic to guide the use of the investigational compound BYL719 (alpelisib) in combination with fulvestrant for men and postmenopausal women living with PIK3CA mutated hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer.

December 4, 2018
The researchers used a next-generation peptide-based immunoassay to subdivide allergenic milk proteins into smaller peptide fragments — called epitopes — and measured the reactivity of the epitopes to a patient’s IgE/IgG4 antibodies
AllerGenis has reported research results in The Journal of Allergy and Clinical Immunology(JACI) that demonstrate the ability to predict, with significant accuracy, milk allergy patients’ outcomes before milk oral immunotherapy treatment (Milk-OIT) is administered, using the company’s novel milk allergy diagnostic assay.  
December 3, 2018
Faecal calprotectin has a prognostic role for disease course in Crohn's disease and studies have suggested a revision of guidelines to incorporate it as a treatment target
The diagnosis of Crohn’s disease (CD) does not rely on a single gold standard but requires the integration of clinical data with endoscopic, histologic, radiological and biochemical investigations.1
December 3, 2018
The study recommends active surveillance to prevent over-treatment, suggesting that 36% of patients with a new diagnosis are candidates for active surveillance, 30% of whom will ultimately have treatment for progression
A new study has confirmed the effectiveness of Prostate-specific Antigen (PSA) screening in reducing prostate cancer mortality.
The retrospective cohort study of over 400,000 men, as published in Elsevier’s Urology® journal,1 set out to re-examine the value of PSA screening, to determine the optimal screening interval and the appropriate age groups to be screened. 
October 12, 2018
The new unit will focus on digital diagnostics and help laboratories, hospitals and other healthcare providers to 'optimise' their performance

Lab solutions company Roche Diagnostics has launched a new business unit called Roche Healthcare Consulting. 
The new unit will focus on digital diagnostics and help laboratories, hospitals and other healthcare providers to “optimise their performance”.
The global consulting service will feature over 250 experienced consultants who specialise in business, healthcare and technology, and will use data analytics and reports to help clients improve their operational, clinical and financial performance.

October 2, 2018
This article focuses on the current technologies used for the enrichment and detection of circulating tumour cells and the innovative technologies that have been developed to improve methods for detection
October 2, 2018
The increasing range and scope of point of care tests in virology means that these assays have the potential to make a valuable contribution to diagnostic virology services
October 2, 2018
This manuscript highlights the results of the 2016 External Quality Assurance scheme for EGFR, ALK and ROS1 biomarker analysis in non-small cell lung cancer
October 2, 2018
Next generation sequencing is practical and reliable to use on tissue specimens and potentially on liquid biopsies, which potentially will further revolutionise the diagnostic landscape of lung cancer
May 22, 2018
GDE Trust of the year Royal Liverpool and Broadgreen University Hospitals NHS Trust working with UK-based artificial intelligence health company, Deontics, to enhance clinical decision making and reduce risk of heart attack

Global Digital Exemplar, Royal Liverpool and Broadgreen University Hospitals NHS Trust is using artificial intelligence (AI) to improve the treatment of patients who have had a heart attack, in a project that could see wider use of AI to inform treatment decisions across the Trust.

May 10, 2018
NHS failure to send invitations may have resulted in women having their lives shortened, according to estimates

Nearly half a million women in England have missed out on a routine breast screening appointment due to an NHS failure to send invitations. 

Up to 270 women may have had their lives shortened as a result, according to estimates. A computer error has been blamed for the missed invitations.

May 3, 2018
AI is now essential for automation in radiology and pathology, but it provides a means to support the human, not replace, writes Chris Scarisbrick, Sectra UK & Ireland

Will I be replaced by a robot? Mainstream media reporting on artificial intelligence has led many people to ask this question.

AI has gone from being the subject of science fiction and theory, to creeping into the reality of everyday life – either augmenting or starting to replace the way people carry out mundane tasks in their homes, in our supermarkets, on our roads and even where we work.

April 11, 2018
Protagen AG and Gustave Roussy have announced the start of a collaboration to utilise proprietary technology to help identify biomarkers that predict and monitor immune-related adverse events in cancer patients treated with checkpoint inhibitors

Checkpoint inhibitors offer enormous potential for the treatment of many cancer indications, including melanoma and renal cell carcinoma. Yet, only a subset of patients respond favorably to treatment and it is not currently possible to predict which patients will benefit from therapy.

April 9, 2018
New centres being set up across the country mark a "step change" in cancer care NHS England said

‘One stop shops’ aimed at speeding up cancer diagnosis are being rolled out across the country, NHS England has announced (3 April).

Rapid diagnostic and assessment centres are being piloted in ten areas as part of NHS England’s drive to catch cancer early and help save lives.

March 2, 2018
Clinical validation was based on the PANOTPIC (PulmonAry NOdule Plasma proTeomIc Classifier) clinical trial, a large prospective lung nodule clinical trial

Integrated Diagnostics has announced the e-publication of full results of a large prospective clinical trial validating its Xpresys Lung 2® in the peer-reviewed medical journal, CHEST.

February 26, 2018
CE-IVD labelled PAXgene® Blood ccfDNA tube will be available in Western Europe

BD has announced the commercial availability of the CE-IVD marked PAXgene® Blood ccfDNA tube within the European Economic Area and Switzerland (Western Europe).

February 25, 2018
Because Parkinson's disease can affect nerve function outside of the brain, the research team hypothesised that any change in nerve function may be seen in the protein levels in tears

Tears may hold clues to whether someone has Parkinson's disease, according to a preliminary study that will be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, 21-27 April 2018.

February 15, 2018
With the current situation, diagnosis of atrial fibrillation is a lengthy and expensive process, sometimes taking years

KardiaMobile, a revolutionary and potentially life-saving heart monitor, is being distributed to the NHS in England.

February 15, 2018
Patient safety and clinical governance are major priorities for any NHS Trust, so ensuring both the accuracy and speed of a test result, and its confirmed match to the patient is essential

Radiometer Ltd has implemented its AQURE Enterprise point-of-care (POC) data management system at the University of Leicester Hospitals NHS Trust’s new Emergency Department.

February 8, 2018
Doctors have developed a new five-minute procedure to scan the blood vessels which offers hope for claustrophobic patients unable to tolerate the conventional longer test

Magnetic resonance angiography (MRA) is a magnetic resonance imaging (MRI) exam that takes pictures of the blood vessels. Physicians use the images to diagnose diseases of the blood vessels, such as aneurysms or blockages.
During the test patients lie on a table inside a tunnel-like tube and must remain still. A dye, called a contrast agent, is injected into the veins so the vessels can be seen more clearly. Patients are given a headset to block out noise from the scanner. An MRA can typically take 30 minutes to one hour, from start to finish.

January 16, 2018
Scientists have made a significant breakthrough in understanding how the molecular machines that produce key proteins in the power packs of cells are cleaned and maintained.

Scientists have made a significant breakthrough in understanding how the molecular machines that produce key proteins in the power packs of cells are cleaned and maintained.

University of Sussex academics, working with colleagues around the globe on a project led by the Institute for Research in Biomedicine (IRB Barcelona), have shown that the enzyme EXD2 is critically involved in maintaining efficient protein production in mitochondria - the compartment responsible for making the energy required for cells to  survive and replicate.